Choroidal Manifestation of Smoldering Myeloma: Case Report

Abstract

This case illustrates clinical, histopathological, immunohistochemical, and molecular pathological diagnostic testing of smoldering myeloma with atypical ophthalmic manifestations. In our case, the choroidal lesion presented as a solitary manifestation of a systemic disease. Choroidal lesions of monoclonal plasma cells are extremely rare and should be included in the differential diagnosis of amelanotic choroidal lesions, even if the histopathological examination of the primary lesion is not informative. Clinical course, immunohistochemistry, and molecular pathology are essential components of the diagnostic pathway.

Zusammenfassung

Dieser Fall schildert klinische, histopathologische, immunhistochemische und molekulare pathologische Diagnoseverfahren beim Smoldering Myelom mit einem atypischen ophthalmologischen Erscheinungsbild. In unserem Fall war die Aderhautläsion die einzige Manifestation einer systemischen Erkrankung. Aderhautläsionen monoklonaler Plasmazellen sind extrem selten und sollten bei der Differenzialdiagnose amelanotischer Aderhautläsionen berücksichtigt werden, selbst wenn eine histopathologische Untersuchung der primären Läsion keinen Aufschluss liefert. Der klinische Verlauf, die Immunhistochemie sowie die molekulare Pathologie sind essenzielle Komponenten des diagnostischen Verlaufs.

Key words

ocular oncology - smoldering myeloma - ophthalmic manifestations of multiple myeloma

Schlüsselwörter

Ophthalmoonkologie - Smoldering Myelom - okuläre Manifestation eines Multiplen Myeloms

Publication History

Received: 10 July 2021

Accepted: 07 April 2022

Article published online:
28 July 2022

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